Gastroesophageal reflux disease is a highly prevalent disease, but remains a common and challenging condition. Treatments should including lifestyle modification and if needed, medications. PPIs remain the mainstay of treatment of GERD. In more severse cases surgery is opted for.  Understanding the pathophysiology of GERD may help in the development of novel therapeutic approaches. Warning signs to watch out for include difficulty swallowing, vomiting, vomiting blood, palpable masses, severe chest pain, unexplained weight loss. Notify your doctor immediately if experience any of these symptoms.